Research

Oncology

Through an integrated functional approach, we are developing new small molecules for ovarian and colon cancers.


Agri-food

Contaminants are a recurring problem in food. We are developing new molecular tests to improve human health.


News

Dallo zafferano nuovi strumenti per contrastare i tumori


Videos

AACR WEBCAST presentations

Genome Editing with CRISPR-Cas9


Conferences

September 13 – 15, 2018, Seattle, Washington, 12th Biennial Ovarian Cancer Research Symposium

September 8-12, Madrid, Spain. ESMO 2017 Congress

APRIL 2-6, 2017, San Francisco, CA. ACS National meeting & Exposition

April 1-5, 2017, Washington, DC. AACR Annual Meeting 2017


Last 5 years publications

2018
Russo Spena C, De Stefano L, Palazzolo S, Salis B, Granchi C, Minutolo F, Tuccinardi T, Fratamico R, Crotti S, D’Aronco S, Agostini M, Corona G, Caligiuri I, Canzonieri V, Rizzolio F. Liposomal delivery of a Pin1 inhibitor complexed with cyclodextrins as new therapy for high-grade serous ovarian cancer. J Control Release. 2018 Jul 10;281:1-10. doi: 10.1016/j.jconrel.2018.04.055. Epub 2018 May 8.

Scattolin T, Caligiuri I, Canovese L, Demitri N, Gambari R, Lampronti I, Rizzolio F, Santo C, Visentin F. Synthesis of new allyl palladium complexes bearing purine-based NHC ligands with antiproliferative and proapoptotic activities on human ovarian cancer cell lines. Dalton Trans. 2018 Oct 2;47(38):13616-13630. doi: 10.1039/c8dt01831f.

Bononi G, Granchi C, Lapillo M, Giannotti M, Nieri D, Fortunato S, Boustani ME, Caligiuri I, Poli G, Carlson KE, Kim SH, Macchia M, Martinelli A, Rizzolio F, Chicca A, Katzenellenbogen JA, Minutolo F, Tuccinardi T. Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors. Eur J Med Chem. 2018 Sep 5;157:817-836. doi: 10.1016/j.ejmech.2018.08.038. Epub 2018 Aug 16.

Cailotto S, Amadio E, Facchin M, Selva M, Pontoglio E, Rizzolio F, Riello P, Toffoli G, Benedetti A, Perosa A. Carbon Dots from Sugars and Ascorbic Acid: Role of the Precursors on Morphology, Properties, Toxicity, and Drug Uptake.

ACS Med Chem Lett. 2018 Jul 16;9(8):832-837. doi: 10.1021/acsmedchemlett.8b00240. eCollection 2018 Aug 9.

Granchi C, Rizzolio F, Caligiuri I, Macchia M, Martinelli A, Minutolo F, Tuccinardi T. Rational Development of MAGL Inhibitors. Methods Mol Biol. 2018;1824:335-346. doi: 10.1007/978-1-4939-8630-9_20.

Poli G, Lapillo M, Granchi C, Caciolla J, Mouawad N, Caligiuri I, Rizzolio F, Langer T, Minutolo F, Tuccinardi T. Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors. J Enzyme Inhib Med Chem. 2018 Dec;33(1):956-961. doi: 10.1080/14756366.2018.1469017.

Farra R, Musiani F, Perrone F, Čemažar M, Kamenšek U, Tonon F, Abrami M, Ručigaj A, Grassi M, Pozzato G, Bonazza D, Zanconati F, Forte G, El Boustani M, Scarabel L, Garziera M, Russo Spena C, De Stefano L, Salis B, Toffoli G, Rizzolio F, Grassi G, Dapas B. Polymer-Mediated Delivery of siRNAs to Hepatocellular Carcinoma: Variables Affecting Specificity and Effectiveness. Molecules. 2018 Mar 28;23(4). pii: E777. doi: 10.3390/molecules23040777. Review.

Dubuc C, Savard M, Bovenzi V, Lessard A, Fortier A, Côté J, Neugebauer W, Rizzolio F, Geha S, Giordano A, Chemtob S, Gobeil F. Targeting intracellular B2 receptors using novel cell-penetrating antagonists to arrest growth and induce apoptosis in human triple-negative breast cancer. Oncotarget. 2018 Jan 5;9(11):9885-9906. doi: 10.18632/oncotarget.24009. eCollection 2018 Feb 9.


2017

Granchi C, Caligiuri I, Bertelli E, Poli G, Rizzolio F, Macchia M, Martinelli A, Minutolo F, Tuccinardi T. Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1240-1252. doi: 10.1080/14756366.2017.1375484.

Palazzolo S, Bayda S, Hadla M, Caligiuri I, Corona G, Toffoli G, Rizzolio F. The Clinical Translation of Organic Nanomaterials for Cancer Therapy: A Focus on Polymeric Nanoparticles, Micelles, Liposomes and Exosomes. Curr Med Chem. 2018;25(34):4224-4268. doi: 10.2174/0929867324666170830113755.

Granchi C, Fortunato S, Meini S, Rizzolio F, Caligiuri I, Tuccinardi T, Lee HY, Hergenrother PJ, Minutolo F. Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer. J Agric Food Chem. 2017 Jul 19;65(28):5639-5649. doi: 10.1021/acs.jafc.7b01668. Epub 2017 Jul 7.

Xu L, Ren Z, Chow FE, Tsai R, Liu T, Rizzolio F, Boffo S, Xu Y, Huang S, Lippa CF, Gong Y.Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer’s Disease. Neural Plast. 2017;2017:3270725. doi: 10.1155/2017/3270725. Epub 2017 Mar 26.

Pellizzoni E, Tommasini M, Marangon E, Rizzolio F, Saito G, Benedetti F, Toffoli G, Resmini M, Berti F. Corrigendum to “Fluorescent molecularly imprinted nanogels for the detection of anticancer drugs in human plasma Biosens Bioelectron. 2017 Aug 15;94:728. doi: 10.1016/j.bios.2017.03.042. Epub 2017 Mar 23.

Scarabel L, Perrone F, Garziera M, Farra R, Grassi M, Musiani F, Russo Spena C, Salis B, De Stefano L, Toffoli G, Rizzolio F, Tonon F, Abrami M, Chiarappa G, Pozzato G, Forte G, Grassi G, Dapas B. Strategies to optimize siRNA delivery to hepatocellular carcinoma cells. Expert Opin Drug Deliv. 2017 Jun;14(6):797-810. doi: 10.1080/17425247.2017.1292247. Epub 2017 Feb 17.

Crotti S, Piccoli M, Rizzolio F, Giordano A, Nitti D, Agostini M. Extracellular Matrix and Colorectal Cancer: How Surrounding Microenvironment Affects Cancer Cell Behavior? J Cell Physiol. 2017 May;232(5):967-975. doi: 10.1002/jcp.25658. Epub 2016 Nov 10. Review.

Zanusso C, Bortolus R, Dreussi E, Polesel J, Montico M, Cecchin E, Gagno S, Rizzolio F, Arcicasa M, Novara G, Toffoli G. Impact of DNA repair gene polymorphisms on the risk of biochemical recurrence after radiotherapy and overall survival in prostate cancer. Oncotarget. 2017 Apr 4;8(14):22863-22875. doi: 10.18632/oncotarget.15282.

Bayda S, Hadla M, Palazzolo S, Kumar V, Caligiuri I, Ambrosi E, Pontoglio E, Agostini M, Tuccinardi T, Benedetti A, Riello P, Canzonieri V, Corona G, Toffoli G, Rizzolio F. Bottom-up synthesis of carbon nanoparticles with higher doxorubicin efficacy. J Control Release. 2017 Feb 28;248:144-152. doi: 10.1016/j.jconrel.2017.01.022. Epub 2017 Jan 14.

Xu L, Ren Z, Chow FE, Tsai R, Liu T, Rizzolio F, Boffo S, Xu Y, Huang S, Lippa CF, Gong Y. Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer’s Disease. Neural Plast. 2017;2017:3270725. doi: 10.1155/2017/3270725. Epub 2017 Mar 26.


2016
Mohamad Hadla, Stefano Palazzolo, Giuseppe Corona, Vincenzo Canzonieri, Giuseppe Toffoli, and Flavio Rizzolio. Exosomes Increase the Therapeutic Index of Doxorubicin in Breast and Ovarian Cancer Mouse Models. Nanomedicine (Lond). 2016 Sep;11(18):2431-41. doi: 10.2217/nnm-2016-0154. Epub 2016 Aug 25.

Millino C, Maretto I, Pacchioni B, Digito M, De Paoli A, Canzonieri V, D’Angelo E, Agostini M, Rizzolio F, Giordano A, Barina A, Rajendran S, Esposito G, Lanfranchi G, Nitti D, Pucciarelli S. Gene and microRNA Expression Are Predictive of Tumor Response in Rectal Adenocarcinoma Patients Treated with Preoperative Chemoradiotherapy. J Cell Physiol. 2016 May 25. doi: 10.1002/jcp.25441. [Epub ahead of print] PMID: 27225591.

Miolo G, Muraro E, Caruso D, Crivellari D, Ash A, Scalone S, Lombardi D, Rizzolio F, Giordano A, Corona G. Phamacometabolomics study identifies circulating spermidine and tryptophan as potential biomarkers associated with the complete pathological response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer. Oncotarget. 2016 May 19. doi: 10.18632/oncotarget.9489. [Epub ahead of print] PMID: 27223427.

Granchi C, Lapillo M, Spena CR, Rizzolio F, Tuccinardi T, Martin TA, Carlson KE, Katzenellenbogen JA, Minutolo F. Cyclic Ketoximes as Estrogen Receptor β Selective Agonists. ChemMedChem. 2016 May 2. doi: 10.1002/cmdc.201600140. [Epub ahead of print] PMID: 27135651.

Kumar V, Palazzolo S, Bayda S, Corona G, Toffoli G, Rizzolio F. DNA Nanotechnology for Cancer Therapy. Theranostics. 2016 Mar 20;6(5):710-25. doi: 10.7150/thno.14203. eCollection 2016. Review. PMID: 27022418.

Granchi C, Rizzolio F, Bordoni V, Caligiuri I, Manera C, Macchia M, Minutolo F, Martinelli A, Giordano A, Tuccinardi T. 4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors. J Enzyme Inhib Med Chem. 2016;31(1):137-46. doi: 10.3109/14756366.2015.1010530.

Kumar V, Bayda S, Hadla M, Caligiuri I, Russo Spena C, Palazzolo S, Kempter S, Corona G, Toffoli G, Rizzolio F. Enhanced Chemotherapeutic Behavior of Open-Caged DNA@Doxorubicin Nanostructures for Cancer Cells. J Cell Physiol. 2016 Jan;231(1):106-10. PMID: 26031628.


2015
Toffoli G, Hadla M, Corona G, Caligiuri I, Palazzolo S, Semeraro S, Gamini A, Canzonieri V, Rizzolio F. Exosomal doxorubicin reduces the cardiac toxicity of doxorubicin. Nanomedicine (Lond). 2015 Sep 30. [Epub ahead of print]. PMID:26420143.

Agostini M, Janssen KP, Kim IJ, D’Angelo E, Pizzini S, Zangrando A, Zanon C, Pastrello C, Maretto I, Digito M, Bedin C, Jurisica I, Rizzolio F, Giordano A, Bortoluzzi S, Nitti D, Pucciarelli S. An integrative approach for the identification of prognostic and predictive biomarkers in rectal cancer. Oncotarget. 2015 Oct 20;6(32):32561-74. PMID: 26359356.

Gabriele Sponchia, Emmanuele Ambrosi, Flavio Rizzolio, Mohamad Hadla, Anna Del Tedesco, Concetta Russo Spena, Giuseppe Toffoli, Pietro Riello and Alvise Benedetti. Biocompatible tailored zirconia mesoporous nanoparticles with high surface area for theranostic applications. J. Mater. Chem. B, 2015,3, 7300-7306. DOI: 10.1039/C5TB01424G.

Bedin C, Crotti S, Ragazzi E, Pucciarelli S, Agatea L, Tasciotti E, Ferrari M, Traldi P, Rizzolio F, Giordano A, Nitti D, Agostini M. Alterations of the Plasma Peptidome Profiling in Colorectal Cancer Progression. J Cell Physiol. 2015 Sep 17. PMID:26379225.

Agostini M, Zangrando A, Pastrello C, D’Angelo E, Romano G, Giovannoni R, Giordan M, Maretto I, Bedin C, Zanon C, Digito M, Esposito G, Mescoli C, Lavitrano M, Rizzolio F, Jurisica I, Giordano A, Pucciarelli S, Nitti D. A functional biological network centered on XRCC3: a new possible marker of chemoradiotherapy resistance in rectal cancer patients. Cancer Biol Ther. 2015;16(8):1160-71. doi: 10.1080/15384047.2015.1046652.

Paterni I, Bertini S, Granchi C, Tuccinardi T, Macchia M, Martinelli A, Caligiuri I, Toffoli G, Rizzolio F, Carlson KE, Katzenellenbogen BS, Katzenellenbogen JA, Minutolo F. Highly selective salicylketoxime-based estrogen receptor β agonists display antiproliferative activities in a glioma model. J Med Chem. 2015 Feb 12;58(3):1184-94. doi: 10.1021/jm501829f.


2014
Crotti S, Enzo MV, Bedin C, Pucciarelli S, Maretto I, Bianco PD, Traldi P, Tasciotti E, Ferrari M, Rizzolio F, Toffoli G, Giordano A, Nitti D, Agostini M. Clinical predictive circulating peptides in rectal cancer patients treated with neoadjuvant chemoradiotherapy. J Cell Physiol. 2014 Dec 17. doi: 10.1002/jcp.24894.

Cecchin E, Perrone G, Nobili S, Polesel J, De Mattia E, Zanusso C, Petreni P, Lonardi S, Pella N, D’Andrea M, Errante D, Rizzolio F, Mazzei T, Landini I, Mini E, Toffoli G. MTHFR-1298 A>C (rs1801131) is a predictor of survival in two cohorts of stage II/III colorectal cancer patients treated with adjuvant fluoropyrimidine chemotherapy with or without oxaliplatin. Pharmacogenomics J. 2014 Oct 21. doi: 10.1038/tpj.2014.64.

Tuccinardi T, Granchi C, Rizzolio F, Caligiuri I, Battistello V, Toffoli G, Minutolo F, Macchia M, Martinelli A. Identification and characterization of a new reversible MAGL inhibitor. Bioorg Med Chem. 2014 Jul 1;22(13):3285-91. doi: 10.1016/j.bmc.2014.04.057.

Corona G, Polesel J, Fratino L, Miolo G, Rizzolio F, Crivellari D, Addobbati R, Cervo S, Toffoli G. Metabolomics biomarkers of frailty in elderly breast cancer patients. J Cell Physiol. 2014 Jul;229(7):898-902. doi: 10.1002/jcp.24520. PMID:24659054.

 

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