Research

Oncology

Through an integrated functional approach, we are developing new small molecules for ovarian and colon cancers.

Agri-food

Contaminants are a recurring problem in food. We are developing new molecular tests to improve human health.

News

Dallo zafferano nuovi strumenti per contrastare i tumori

Videos

AACR WEBCAST presentations

Genome Editing with CRISPR-Cas9

Conferences

September 8-12, Madrid, Spain. ESMO 2017 Congress

APRIL 2-6, 2017, San Francisco, CA. ACS National meeting & Exposition

April 1-5, 2017, Washington, DC. AACR Annual Meeting 2017

Last 5 years publications

2017
Scarabel L, Perrone F, Garziera M, Farra R, Grassi M, Musiani F, Russo Spena C, Salis B, De Stefano L, Toffoli G, Rizzolio F, Tonon F, Abrami M, Chiarappa G, Pozzato G, Forte G, Grassi G, Dapas B. Strategies to optimize siRNA delivery to hepatocellular carcinoma cells. Expert Opin Drug Deliv. 2017 Jun;14(6):797-810. doi: 10.1080/17425247.2017.1292247. Epub 2017 Feb 17.

Crotti S, Piccoli M, Rizzolio F, Giordano A, Nitti D, Agostini M. Extracellular Matrix and Colorectal Cancer: How Surrounding Microenvironment Affects Cancer Cell Behavior? J Cell Physiol. 2017 May;232(5):967-975. doi: 10.1002/jcp.25658. Epub 2016 Nov 10. Review.

Zanusso C, Bortolus R, Dreussi E, Polesel J, Montico M, Cecchin E, Gagno S, Rizzolio F, Arcicasa M, Novara G, Toffoli G. Impact of DNA repair gene polymorphisms on the risk of biochemical recurrence after radiotherapy and overall survival in prostate cancer. Oncotarget. 2017 Apr 4;8(14):22863-22875. doi: 10.18632/oncotarget.15282.

Bayda S, Hadla M, Palazzolo S, Kumar V, Caligiuri I, Ambrosi E, Pontoglio E, Agostini M, Tuccinardi T, Benedetti A, Riello P, Canzonieri V, Corona G, Toffoli G, Rizzolio F. Bottom-up synthesis of carbon nanoparticles with higher doxorubicin efficacy. J Control Release. 2017 Feb 28;248:144-152. doi: 10.1016/j.jconrel.2017.01.022. Epub 2017 Jan 14.

Xu L, Ren Z, Chow FE, Tsai R, Liu T, Rizzolio F, Boffo S, Xu Y, Huang S, Lippa CF, Gong Y. Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer’s Disease. Neural Plast. 2017;2017:3270725. doi: 10.1155/2017/3270725. Epub 2017 Mar 26.

2016
Mohamad Hadla, Stefano Palazzolo, Giuseppe Corona, Vincenzo Canzonieri, Giuseppe Toffoli, and Flavio Rizzolio. Exosomes Increase the Therapeutic Index of Doxorubicin in Breast and Ovarian Cancer Mouse Models. Nanomedicine (Lond). 2016 Sep;11(18):2431-41. doi: 10.2217/nnm-2016-0154. Epub 2016 Aug 25.

Millino C, Maretto I, Pacchioni B, Digito M, De Paoli A, Canzonieri V, D’Angelo E, Agostini M, Rizzolio F, Giordano A, Barina A, Rajendran S, Esposito G, Lanfranchi G, Nitti D, Pucciarelli S. Gene and microRNA Expression Are Predictive of Tumor Response in Rectal Adenocarcinoma Patients Treated with Preoperative Chemoradiotherapy. J Cell Physiol. 2016 May 25. doi: 10.1002/jcp.25441. [Epub ahead of print] PMID: 27225591.

Miolo G, Muraro E, Caruso D, Crivellari D, Ash A, Scalone S, Lombardi D, Rizzolio F, Giordano A, Corona G. Phamacometabolomics study identifies circulating spermidine and tryptophan as potential biomarkers associated with the complete pathological response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer. Oncotarget. 2016 May 19. doi: 10.18632/oncotarget.9489. [Epub ahead of print] PMID: 27223427.

Granchi C, Lapillo M, Spena CR, Rizzolio F, Tuccinardi T, Martin TA, Carlson KE, Katzenellenbogen JA, Minutolo F. Cyclic Ketoximes as Estrogen Receptor β Selective Agonists. ChemMedChem. 2016 May 2. doi: 10.1002/cmdc.201600140. [Epub ahead of print] PMID: 27135651.

Kumar V, Palazzolo S, Bayda S, Corona G, Toffoli G, Rizzolio F. DNA Nanotechnology for Cancer Therapy. Theranostics. 2016 Mar 20;6(5):710-25. doi: 10.7150/thno.14203. eCollection 2016. Review. PMID: 27022418.

Granchi C, Rizzolio F, Bordoni V, Caligiuri I, Manera C, Macchia M, Minutolo F, Martinelli A, Giordano A, Tuccinardi T. 4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors. J Enzyme Inhib Med Chem. 2016;31(1):137-46. doi: 10.3109/14756366.2015.1010530.

Kumar V, Bayda S, Hadla M, Caligiuri I, Russo Spena C, Palazzolo S, Kempter S, Corona G, Toffoli G, Rizzolio F. Enhanced Chemotherapeutic Behavior of Open-Caged DNA@Doxorubicin Nanostructures for Cancer Cells. J Cell Physiol. 2016 Jan;231(1):106-10. PMID: 26031628.

2015
Toffoli G, Hadla M, Corona G, Caligiuri I, Palazzolo S, Semeraro S, Gamini A, Canzonieri V, Rizzolio F. Exosomal doxorubicin reduces the cardiac toxicity of doxorubicin. Nanomedicine (Lond). 2015 Sep 30. [Epub ahead of print]. PMID:26420143.

Agostini M, Janssen KP, Kim IJ, D’Angelo E, Pizzini S, Zangrando A, Zanon C, Pastrello C, Maretto I, Digito M, Bedin C, Jurisica I, Rizzolio F, Giordano A, Bortoluzzi S, Nitti D, Pucciarelli S. An integrative approach for the identification of prognostic and predictive biomarkers in rectal cancer. Oncotarget. 2015 Oct 20;6(32):32561-74. PMID: 26359356.

Gabriele Sponchia, Emmanuele Ambrosi, Flavio Rizzolio, Mohamad Hadla, Anna Del Tedesco, Concetta Russo Spena, Giuseppe Toffoli, Pietro Riello and Alvise Benedetti. Biocompatible tailored zirconia mesoporous nanoparticles with high surface area for theranostic applications. J. Mater. Chem. B, 2015,3, 7300-7306. DOI: 10.1039/C5TB01424G.

Bedin C, Crotti S, Ragazzi E, Pucciarelli S, Agatea L, Tasciotti E, Ferrari M, Traldi P, Rizzolio F, Giordano A, Nitti D, Agostini M. Alterations of the Plasma Peptidome Profiling in Colorectal Cancer Progression. J Cell Physiol. 2015 Sep 17. PMID:26379225.

Agostini M, Zangrando A, Pastrello C, D’Angelo E, Romano G, Giovannoni R, Giordan M, Maretto I, Bedin C, Zanon C, Digito M, Esposito G, Mescoli C, Lavitrano M, Rizzolio F, Jurisica I, Giordano A, Pucciarelli S, Nitti D. A functional biological network centered on XRCC3: a new possible marker of chemoradiotherapy resistance in rectal cancer patients. Cancer Biol Ther. 2015;16(8):1160-71. doi: 10.1080/15384047.2015.1046652.

Paterni I, Bertini S, Granchi C, Tuccinardi T, Macchia M, Martinelli A, Caligiuri I, Toffoli G, Rizzolio F, Carlson KE, Katzenellenbogen BS, Katzenellenbogen JA, Minutolo F. Highly selective salicylketoxime-based estrogen receptor β agonists display antiproliferative activities in a glioma model. J Med Chem. 2015 Feb 12;58(3):1184-94. doi: 10.1021/jm501829f.

2014
Crotti S, Enzo MV, Bedin C, Pucciarelli S, Maretto I, Bianco PD, Traldi P, Tasciotti E, Ferrari M, Rizzolio F, Toffoli G, Giordano A, Nitti D, Agostini M. Clinical predictive circulating peptides in rectal cancer patients treated with neoadjuvant chemoradiotherapy. J Cell Physiol. 2014 Dec 17. doi: 10.1002/jcp.24894.

Cecchin E, Perrone G, Nobili S, Polesel J, De Mattia E, Zanusso C, Petreni P, Lonardi S, Pella N, D’Andrea M, Errante D, Rizzolio F, Mazzei T, Landini I, Mini E, Toffoli G. MTHFR-1298 A>C (rs1801131) is a predictor of survival in two cohorts of stage II/III colorectal cancer patients treated with adjuvant fluoropyrimidine chemotherapy with or without oxaliplatin. Pharmacogenomics J. 2014 Oct 21. doi: 10.1038/tpj.2014.64.

Tuccinardi T, Granchi C, Rizzolio F, Caligiuri I, Battistello V, Toffoli G, Minutolo F, Macchia M, Martinelli A. Identification and characterization of a new reversible MAGL inhibitor. Bioorg Med Chem. 2014 Jul 1;22(13):3285-91. doi: 10.1016/j.bmc.2014.04.057.

Corona G, Polesel J, Fratino L, Miolo G, Rizzolio F, Crivellari D, Addobbati R, Cervo S, Toffoli G. Metabolomics biomarkers of frailty in elderly breast cancer patients. J Cell Physiol. 2014 Jul;229(7):898-902. doi: 10.1002/jcp.24520. PMID:24659054.

2013
Kumar Vinit, Toffoli Giuseppe, Rizzolio Flavio. Fluorescent Carbon Nanoparticles in Medicine for Cancer Therapy. ACS Med Chem Lett. 2013 Oct 24;4(11):1012-3. doi: 10.1021/ml400394a.

Poli G, Tuccinardi T, Rizzolio F, Caligiuri I, Botta L, Granchi C, Ortore G, Minutolo F, Schenone S, Martinelli A. Identification of new Fyn kinase inhibitors using a FLAP-based approach. J Chem Inf Model. 2013 Oct 28;53(10):2538-47. doi: 10.1021/ci4002553.

Ciarcia R, Damiano S, Montagnaro S, Pagnini U, Ruocco A, Caparrotti G, d’Angelo D, Boffo S, Morales F, Rizzolio F, Florio S, Giordano A. Combined effects of PI3K and SRC kinase inhibitors with imatinib on intracellular calcium levels, autophagy, and apoptosis in CML-PBL cells. Cell Cycle. 2013 Sep 1;12(17):2839-48. doi: 10.4161/cc.25920.

Isabella Caligiuri, Giuseppe Toffoli, Antonio Giordano and Flavio Rizzolio. pRb controls Estrogen Receptor alpha protein stability and activity. Oncotarget. 2013, June 3. PMID: 23900261.

Lucchetti C, Caligiuri I, Toffoli G, Giordano A, Rizzolio F. The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor α in breast cancer. PLoS One. 2013;8(2):e55355. doi: 10.1371/journal.pone.0055355.

Alessio N, Bohn W, Rauchberger V, Rizzolio F, Cipollaro M, Rosemann M, Irmler M, Beckers J, Giordano A, Galderisi U. Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells. Cell Mol Life Sci. 2013 May;70(9):1637-51. doi: 10.1007/s00018-012-1224-x.

La Montagna R, Caligiuri I, Giordano A, Rizzolio F. Pin1 and nuclear receptors: A new language? J Cell Physiol. 2013 Sep;228(9):1799-801. doi: 10.1002/jcp.24316. Review.

2012
Toffoli G, Castronovo M, Rizzolio F. Nanotechnology for Circulating Tumor Biomarker Analysis. J Biomark Drug Dev. 2012 Nov 06.

Marchesi I, Fiorentino FP, Rizzolio F, Giordano A, Bagella L. The ablation of EZH2 uncovers its crucial role in rhabdomyosarcoma formation. Cell Cycle. 2012 Oct 15;11(20):3828-36. doi: 10.4161/cc.22025.

Mangani D, Roberti A, Rizzolio F, Giordano A. Emerging molecular networks in Burkitt’s lymphoma. J Cell Biochem. 2012 Aug 17. doi: 10.1002/jcb.24358.

La Montagna R, Caligiuri I, Maranta P, Lucchetti C, Esposito L, Paggi MG, Toffoli G, Rizzolio F, Giordano A. Androgen receptor serine 81 mediates Pin1 interaction and activity. Cell Cycle. 2012 Sep 15;11(18). PMID: 22894932.

Rizzolio F, Caligiuri I, Lucchetti C, Fratamico R, Tomei V, Gallo G, Agelan A, Ferrari G, Toffoli G, Klein-Szanto AJ, Giordano A. Dissecting Pin1 and phospho-pRb regulation. J Cell Physiol. 2012 May 2. doi: 10.1002/jcp.24107.

Manera C, Saccomanni G, Malfitano AM, Bertini S, Castelli F, Laezza C, Ligresti A, Lucchesi V, Tuccinardi T, Rizzolio F, Bifulco M, Di Marzo V, Giordano A, Macchia M, Martinelli A. Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold. Eur J Med Chem. 2012 Jun;52:284-94. PMID: 22483967.

Rizzolio F, Lucchetti C, Caligiuri I, Marchesi I, Caputo M, Klein-Szanto AJ, Bagella L, Castronovo M, Giordano A. Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1. Cell Death Differ. 2012 Feb 10. doi: 10.1038/cdd.2011.202.

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